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P-values and decision-making: discussion of 'Limitations of empirical calibration of p-values using observational
1Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, U.S.A.
Abstract:
Gruber and Tchetgen Tchetgen bring up many important limitations of p-value calibration as applied to the assessment of the safety and effectiveness of medications in secondary administrative data. In this discussion, I further examine the role of study design and selection of comparators in interpreting p-value calibration results, and we consider the advantages and disadvantages of automation in the epidemiology of medications, including p-value calibration. Copyright © 2016 John Wiley & Sons, Ltd.
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