Related Experiment Video
Updated: Mar 15, 2026

08:25
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
3.6K
Cosmetic components causing contact urticaria: a review and update
1Department of Dermatology, University Hospitals KU Leuven, Leuven, 3000, Belgium.
Contact Dermatitis
|September 6, 2016
Summary
Immediate skin reactions from cosmetics, like contact urticaria, are common but often missed. This review details cosmetic ingredients causing these reactions and diagnostic methods, highlighting the need for better research.
Area of Science:
- Dermatology
- Cosmetic Science
- Allergology
Background:
- Immediate skin reactions, such as contact urticaria, are frequently encountered in dermatology.
- These reactions to cosmetic ingredients are often underdiagnosed or overlooked.
- Contact urticaria syndrome presents with diverse clinical manifestations.
Purpose of the Study:
- To update the literature on immediate-type reactions caused by cosmetic ingredients.
- To review clinical symptoms, diagnostic testing (prick, scratch, open testing), and IgE detection.
- To identify specific cosmetic ingredients associated with contact urticaria.
Main Methods:
- A selective literature search was performed across multiple medical databases.
- The search focused on immediate reactions, contact urticaria, and cosmetic ingredients.
- Case reports and studies investigating diagnostic methods were reviewed.
Main Results:
- Numerous cosmetic ingredients were identified as triggers for immediate reactions.
- Common culprits include hair dyes, preservatives, fragrances, sunscreens, and tattoo inks.
- Diagnostic methods like prick testing showed positive reactions, though many studies lacked controls.
Conclusions:
- Contact urticaria from cosmetics is a significant clinical issue.
- A wide array of cosmetic components can induce immediate hypersensitivity.
- Further rigorous investigation and controlled studies are necessary to better understand these reactions.
Related Concept Videos
Drug Toxicity: Allergic Reactions
91
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
91
Allergic Reactions: Anaphylaxis
111
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
111
Allergic Drug Reactions
1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Hypersensitivity Reactions: Immune-Complex Reactions
86
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
86
Allergic Reactions
33.3K
Overview
33.3K
Hypersensitivities
8.1K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
8.1K

