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Updated: Jul 16, 2026
11:36
Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Active chronic hepatitis and febrile panniculitis
A K Banerjee1, S L Grainger, D R Davies
1Gastrointestinal Laboratory, Rayne Institute, St Thomas' Hospital, London.
Gut
|July 1, 1989
Summary
Two patients with autoimmune hepatitis B negative chronic hepatitis and febrile panniculitis experienced symptom relief with increased prednisolone dosage. This suggests prednisolone may effectively manage this rare condition.
Area of Science:
- Hepatology
- Dermatology
- Immunology
Background:
- Autoimmune hepatitis B negative chronic hepatitis is a rare liver condition.
- Febrile panniculitis is an inflammatory condition affecting subcutaneous fat, often associated with systemic diseases.
Observation:
- Two patients presented with concurrent autoimmune hepatitis B negative chronic hepatitis and febrile panniculitis.
- Both patients exhibited a positive response to escalating doses of prednisolone for their panniculitis.
Findings:
- Increased prednisolone dosage led to the resolution of febrile panniculitis in both cases.
- The study highlights a potential therapeutic approach for this specific combination of conditions.
Implications:
- This case series suggests prednisolone as a viable treatment option for febrile panniculitis in the context of autoimmune hepatitis B negative chronic hepatitis.
- Further research is warranted to explore the underlying mechanisms and long-term efficacy of steroid treatment in such cases.
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