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Nanotechnology-Based Surface Plasmon Resonance Affinity Biosensors for In Vitro Diagnostics
Riccarda Antiochia1, Paolo Bollella1, Gabriele Favero1
1Department of Chemistry and Drug Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
International Journal of Analytical Chemistry
|September 6, 2016
Summary
Recent advances in nanostructured surface plasmon resonance biosensors enhance in vitro diagnostic devices (IVDDs). This review compares their assembly and performance in biological samples for improved medical diagnostics.
Area of Science:
- Nanotechnology and Biomedical Engineering
- Analytical Chemistry
- Medical Diagnostics
Background:
- In vitro diagnostic devices (IVDDs) are crucial for early diagnosis, population screening, and therapy assessment.
- Surface plasmon resonance (SPR) biosensors offer high sensitivity for detecting biomarkers.
Purpose of the Study:
- To critically review recent developments in nanostructured SPR biosensors for IVDDs.
- To compare the assembly and performance of these biosensors in biological samples.
Main Methods:
- Literature review of nanostructured SPR biosensor configurations.
- Analysis of biosensor assembly strategies.
- Comparison of biosensor performance metrics in biological matrices.
Main Results:
- Nanostructured materials significantly enhance SPR biosensor sensitivity and specificity.
- Various nanostructure designs offer different advantages for IVDD applications.
- Performance in real biological samples is a key factor for clinical translation.
Conclusions:
- Nanostructured SPR biosensors represent a promising frontier for advanced IVDDs.
- Further research is needed to optimize assembly and validate performance in diverse biological samples.
- These devices hold potential for revolutionizing early disease detection and monitoring.
