Sepicanin A- A new geranyl flavanone from Artocarpus sepicanus with activity against methicillin-resistant
Mohamed M Radwan1, Raquel Rodriguez-Guzman2, Susan P Manly1
1National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Abstract:
Bioassay-guided fractionation of the EtOH extract of Artocarpus sepicanus Diels leaves has led to the isolation of a new geranyl flavanone (1), along with the known compounds, afzelechin-3-O-α-L-rhamnopyranoside and β-sitosterol glucoside. The structure of the new compound was established by UV, IR, HRESIMS, 1D and 2D NMR experiments. Antimicrobial testing of the three compounds indicated that 1 displayed a significant selective antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) with IC50 and MIC values of 1.4 and 2.9 μM, respectively.
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