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Related Experiment Video

Updated: Mar 15, 2026

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

Renal Afferents.

Alissa A Frame¹, Casey Y Carmichael¹, Richard D Wainford²

¹Department of Pharmacology & Experimental Therapeutics and The Whitaker Cardiovascular Institute Boston University School of Medicine, 72 East Concord St, Boston, 02118, MA, USA.

Current Hypertension Reports

|September 6, 2016

Summary

Renal sympathetic nerves play a key role in hypertension. Understanding their afferent and efferent functions offers new therapeutic targets for managing high blood pressure and related diseases.

Keywords:

Hypertension Radiofrequency ablation Renal afferent nerves Renal denervation Renal efferent nerves Sympathetic nervous system

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Last Updated: Mar 15, 2026

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Published on: September 11, 2018

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Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors

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Published on: June 7, 2016

Area of Science:

Nephrology
Cardiovascular Science
Neuroscience

Background:

Hypertension affects one in three US adults, involving multiple organ systems.
Renal sympathetic nerves, with afferent and efferent components, are crucial in hypertension etiology.
These nerves are a significant therapeutic target for hypertension and related conditions.

Purpose of the Study:

To review recent clinical and basic science advances on renal sympathetic nerves in hypertension.
To focus on the role of renal afferent nerves in various hypertension subtypes.
To explore novel therapeutic targets by understanding differential nerve roles.

Main Methods:

Review of recent clinical and basic science literature.
Analysis of studies on renal sympathetic nerve distribution, function, and reinnervation.
Focus on afferent versus efferent nerve roles in hypertension pathophysiology.

Main Results:

Recent advances provide new insights into renal sympathetic nerve distribution and function.
The differential roles of renal afferent and efferent nerves in hypertension are increasingly understood.
Specific insights into salt-sensitive hypertension, obesity-induced hypertension, and chronic kidney disease are highlighted.

Conclusions:

Understanding renal sympathetic nerve function, particularly afferent nerves, is key to hypertension research.
This knowledge can lead to refined therapeutic interventions for hypertension.
Targeting renal sympathetic nerves offers potential for novel hypertension treatments.