Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tunable self-assembling cellular microarray for single-neutrophil vital and suicidal extracellular traps.

Lab on a chip·2026
Same author

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD.

Annals of clinical and translational neurology·2026
Same author

Multidimensional Cellular Micro-Compartments to Model Invasive Lobular Carcinoma Dormancy.

Advanced healthcare materials·2026
Same author

Acoustofluidic Focusing for High-Throughput and Sensitive Analysis of Shape-Encoded Hydrogel Microparticles in Multiplex Immunoassay.

ACS sensors·2026
Same author

Forced-Convection Porous Hydrogel Platform for Rapid miRNA Detection.

Analytical chemistry·2026
Same author

The study of transdermal delivery mechanism of liposomes using stratum corneum lipid membrane model.

Colloids and surfaces. B, Biointerfaces·2026

Related Experiment Video

Updated: Mar 15, 2026

A Paired Bead and Magnet Array for Molding Microwells with Variable Concave Geometries
11:42

A Paired Bead and Magnet Array for Molding Microwells with Variable Concave Geometries

Published on: January 28, 2018

9.3K

Porous microwells for geometry-selective, large-scale microparticle arrays.

Jae Jung Kim1, Ki Wan Bong2,3, Eduardo Reátegui2,4

  • 1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Nature Materials
|September 6, 2016
PubMed
Summary

We developed a novel porous microwell method for creating large-scale microparticle arrays (LSMAs). This technique enables precise particle arrangement for diverse bioengineering and material science applications.

More Related Videos

Photodegradable Hydrogel Interfaces for Bacteria Screening, Selection, and Isolation
07:28

Photodegradable Hydrogel Interfaces for Bacteria Screening, Selection, and Isolation

Published on: November 4, 2021

3.4K
Formation of Biomembrane Microarrays with a Squeegee-based Assembly Method
07:56

Formation of Biomembrane Microarrays with a Squeegee-based Assembly Method

Published on: May 8, 2014

14.2K

Related Experiment Videos

Last Updated: Mar 15, 2026

A Paired Bead and Magnet Array for Molding Microwells with Variable Concave Geometries
11:42

A Paired Bead and Magnet Array for Molding Microwells with Variable Concave Geometries

Published on: January 28, 2018

9.3K
Photodegradable Hydrogel Interfaces for Bacteria Screening, Selection, and Isolation
07:28

Photodegradable Hydrogel Interfaces for Bacteria Screening, Selection, and Isolation

Published on: November 4, 2021

3.4K
Formation of Biomembrane Microarrays with a Squeegee-based Assembly Method
07:56

Formation of Biomembrane Microarrays with a Squeegee-based Assembly Method

Published on: May 8, 2014

14.2K

Area of Science:

  • Material Science
  • Bioengineering
  • Microfluidics

Background:

  • Existing methods for large-scale microparticle arrays (LSMAs) face limitations in scalability, precision, specificity, and versatility.
  • There is a need for advanced techniques to create complex microparticle arrangements for various scientific applications.

Purpose of the Study:

  • To present a new porous microwell-based approach for fabricating large-scale microparticle arrays (LSMAs) with complex motifs.
  • To enable precise sorting and arrangement of microparticles based on physical properties.
  • To demonstrate the versatility of the method through diverse applications.

Main Methods:

  • Utilized fluid flow through porous microwells to guide and assemble microparticles.
  • Developed a scaling theory for rational design of microparticle arrays based on particle size, shape, or modulus.
  • Implemented sequential assembly for complex particle arrangements and pattern transfer.

Main Results:

  • Successfully created large-scale microparticle arrays with complex motifs.
  • Demonstrated sorting and arraying of particles based on physical characteristics.
  • Achieved proximal and nested particle arrangements, along with pattern transfer capabilities.

Conclusions:

  • The porous microwell approach offers a scalable, precise, and versatile platform for creating advanced microparticle arrays.
  • This method has significant potential in high-throughput biological assays, microenvironment engineering, and creating covert tags.