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Morphometric analysis of nuclear/cytoplasmic ratios in normal and perineoplastic vulvar skin
J C Dalrymple1, A K Brough, J M Monaghan
1Regional Gynaecological Oncology Unit, Queen Elizabeth II Hospital, Gateshead, UK.
Histopathology
|June 1, 1989
Abstract:
Analysis of vulvar skin adjacent to squamous carcinoma has demonstrated abnormal deoxyribonucleic acid (DNA) content in histologically unremarkable specimens. Analysis of DNA by microdensitometry is time-consuming. Morphometric analysis by point counting was used to compare the nuclear/cytoplasmic ratios of normal vulvar skin and skin adjacent to malignancy. This showed elevated ratios in the latter specimens although there was no linear relationship to increasing ploidy.