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Effect of pregnancy-specific β1-glycoprotein on indoleamine-2,3-dioxygenase activity in human monocytes

S A Zamorina1,2, V P Timganova3, M S Bochkova3

  • 1Institute of Ecology and Genetics of Microorganisms, Ural Division, Russian Academy of Sciences, Perm, Russia. mantissa7@mail.ru.

Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
|September 7, 2016
PubMed

The role of heterogenic human pregnancy-specific glycoprotein (PSG), obtained by the authors' technology, in the regulation of the indoleamine-2,3-dioxygenase (IDO) activity in female blood monocytes has been studied in vitro. PSG stimulated IDO activity under the conditions of induction of the monocytes by interferon-γ. Upon the induction of cell proliferation by lipopolysaccharides, the stimulating effect was obtained only with 10 μg/mL of PSG. Enhanced IDO activity is probably a factor of peripheral immunological tolerance and antimicrobial protection against intracellular infections in the gestation period.

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Transcytosis of IgG01:15

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IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...