Effect of capsaicin on triglyceride accumulation & secretion in ethanol fed rats

Rats fed capsaicin (0.15, 1.5 and 15 mg%) containing diets were able to counter by about 30 per cent of the hepatic lipid accumulation caused by a single dose administration of ethanol (6 g/kg body weight). The rate of triglyceride secretion in capsaicin fed animals from liver to plasma was also elevated as judged by Triton WR-1339 induced hypertriglyceridemia. The results suggest a possible mechanism by which capsaicin counters ethanol induced hepatic lipid accumulation in rats.