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Updated: Mar 15, 2026

Assays for the Degradation of Misfolded Proteins in Cells
Published on: August 28, 2016
Neurodegenerative diseases linked to misfolded proteins and their therapeutic approaches: A review
Hena Khanam1, Abad Ali1, Mohd Asif1
1Steroid Research Laboratory, Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India.
Abstract:
Neurodegenerative diseases, such as Alzheimer's, Parkinson's, Creutzfeldt-Jacob, Huntington's diseases and amyotrophic lateral sclerosis, are mainly characterized by the massive deposition of misfolded protein aggregates consequent to aberrant production or overexpression of specific proteins. The development of new therapeutics for the treatment of neurodegenerative pathophysiologies currently stands at a crossroads. This presents an opportunity to transition future drug discovery efforts to target disease modification, an area in which much still remains unknown. In this review we examine recent progress in the area of neurodegenerative drug discovery, focusing on some of the most common targets.
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