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Published on: March 27, 2018
Osteopontin in relation to Prognosis following Coronary Artery Bypass Graft Surgery
Eftihia Sbarouni1, Panagiota Georgiadou1, Sofia Chatzikyriakou1
12nd Division of Interventional Cardiology, Onassis Cardiac Surgery Center, 17674 Athens, Greece.
Insights
Preoperative osteopontin (OPN) levels in patients undergoing coronary artery bypass grafting (CABG) were assessed. While OPN correlated with risk factors like prior heart attack, it did not independently predict adverse cardiovascular events post-surgery.
Area of Science:
- Cardiology
- Biomarkers
- Cardiac Surgery
Background:
- Cardiovascular events can occur post-coronary artery bypass grafting (CABG) despite complete revascularization.
- Osteopontin (OPN) is a protein that may play a role in cardiovascular disease.
- Preoperative risk assessment is crucial for patients undergoing CABG.
Purpose of the Study:
- To investigate the association between preoperative osteopontin (OPN) levels and cardiovascular outcomes in patients undergoing elective Coronary Artery Bypass Grafting (CABG).
- To determine if OPN levels can predict major adverse cardiovascular events after CABG surgery.
Main Methods:
- Prospective study of 131 patients undergoing elective CABG with measurement of preoperative plasma osteopontin (OPN) levels.
- Patients were followed for a median of 12 months for a composite endpoint of cardiovascular death, nonfatal myocardial infarction, repeat revascularization, or hospitalization.
- Statistical analysis included comparisons between groups and hazard ratio calculations.
Main Results:
- Patients with a history of acute myocardial infarction (AMI) had significantly higher preoperative OPN levels.
- Preoperative OPN levels showed a positive correlation with the logistic EuroScore.
- Preoperative OPN levels did not differ between patients with and without major adverse events during follow-up and did not independently predict outcomes.
Conclusions:
- Osteopontin (OPN) is associated with preoperative risk factors in patients undergoing low-risk Coronary Artery Bypass Grafting (CABG), including prior acute myocardial infarction and EuroScore.
- OPN did not independently predict adverse cardiovascular events in this patient cohort.
- Further research may explore the role of OPN in cardiovascular disease pathogenesis or as a biomarker in different clinical settings.
Abstract:
Cardiovascular events may occur even after complete revascularization in patients with coronary artery disease. We measured preoperative osteopontin (OPN) levels in 131 consecutive patients (66.5 ± 10 years old, 117 men and 14 women) with left ventricular ejection fraction of 50.7 ± 9.2% and low logistic EuroScore (3.5 ± 3.2%) undergoing elective Coronary Artery Bypass Grafting (CABG) surgery. Patients were prospectively followed up for a median of 12 months (range 11-24). The primary study endpoint was the composite of cardiovascular death, nonfatal myocardial infarction, need for repeat revascularization, and hospitalization for cardiovascular events. Pre-op OPN plasma levels were 77.9 (49.5, 150.9). Patients with prior acute myocardial infarction (AMI) had significantly higher OPN levels compared to those without [131.5 (52.2, 219) versus 73.3 (45.1, 125), p = 0.007]. OPN levels were positively related to EuroScore (r = 0.2, p = 0.031). Pre-op OPN levels did not differ between patients who had a major adverse event during follow-up compared to those with no event (p = 0.209) and had no effect on the hazard of future adverse cardiac events [HR (95% CI): 1.48 (0.43-4.99), p = 0.527]. The history of AMI was associated with increased risk of subsequent cardiovascular events at follow-up (p = 0.02). OPN is associated with preoperative risk assessment prior to low-risk CABG but did not independently predict outcome.
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