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Polymyalgia Rheumatica Revealing a Lymphoma: A Two-Case Report

Frank Verhoeven1, Xavier Guillot1, Mickaël Chouk1

  • 1Department of Rheumatology, CHRU Besançon, 2 Boulevard Fleming, 25030 Besançon, France.

Case Reports in Rheumatology
|September 7, 2016
PubMed

Insights

Polymyalgia rheumatica (PMR) can be linked to lymphoma. Positron emission tomography-computed tomography (PET-CT) aids in diagnosing PMR and detecting underlying cancers like lymphoma.

Area of Science:

  • Rheumatology
  • Oncology
  • Nuclear Medicine

Background:

  • Polymyalgia rheumatica (PMR) is a common inflammatory condition in older adults.
  • The association between PMR and cancer, particularly lymphoma, is debated.
  • Early diagnosis of underlying malignancy is crucial for effective patient management.

Purpose of the Study:

  • To investigate the potential link between Polymyalgia rheumatica (PMR) and lymphoma.
  • To highlight the utility of Positron Emission Tomography-Computed Tomography (PET-CT) in diagnosing PMR and associated malignancies.
  • To present two cases of PMR preceding lymphoma diagnosis.

Main Methods:

  • Case report of two elderly male patients presenting with PMR symptoms.
  • Diagnostic workup included blood tests, bone marrow biopsy, and PET-CT scans.
  • Treatment involved prednisone and assessment of response.

Main Results:

  • Case 1: An 84-year-old man diagnosed with marginal zone B cell lymphoma after presenting with PMR symptoms.
  • Case 2: A 73-year-old man diagnosed with low-grade follicular lymphoma after presenting with PMR symptoms and findings on PET-CT.
  • Both patients responded well to prednisone treatment.

Conclusions:

  • Lymphoma may be present at the time of PMR diagnosis.
  • PET-CT is a valuable tool for the initial assessment of PMR, aiding in the detection of occult malignancies.
  • Prompt diagnosis and management of associated cancers improve patient outcomes.

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