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Association between Stable Coronary Artery Disease and In Vivo Thrombin Generation

Benjamin Valente-Acosta1, Manuel Alfonso Baños-González2, Marco Antonio Peña-Duque3

  • 1Instituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, 14080 México City, Mexico; Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510 México City, Mexico.

Cardiology Research and Practice
|September 7, 2016
PubMed

Insights

Elevated thrombin-antithrombin (TAT) complex levels indicate increased thrombin generation and are associated with the presence and severity of coronary artery disease (CAD) in stable patients.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Clinical Research

Background:

  • Thrombin plays a crucial role in atherosclerotic progression.
  • Enhanced thrombin generation is observed in atherosclerosis.
  • The direct link between thrombin generation and coronary atherosclerotic burden in stable CAD patients remains unproven.

Purpose of the Study:

  • To investigate the association between thrombin-antithrombin (TAT) complex levels and homocysteine levels.
  • To determine the relationship between TAT levels and the presence of coronary artery disease (CAD) diagnosed via coronary angiography.
  • To assess the correlation between TAT levels and the severity of CAD in stable patients.

Main Methods:

  • A study involving 95 stable patients, with 63 diagnosed with significant CAD and 32 without.
  • Measurement of thrombin-antithrombin (TAT) complex and homocysteine concentrations in all participants.
  • Coronary angiography was used to diagnose and assess the severity of CAD.

Main Results:

  • Patients with CAD showed significantly higher concentrations of TAT and homocysteine compared to those without CAD.
  • TAT levels were positively correlated with the severity of CAD, with higher levels observed in patients with trivascular obstruction.
  • A significant association was found between TAT levels and the presence and extent of coronary atherosclerotic burden.

Conclusions:

  • In vivo thrombin generation, indicated by TAT complexes, is significantly associated with both the presence and severity of coronary artery disease.
  • TAT complex levels serve as a potential biomarker for assessing CAD burden in stable patients.
  • These findings highlight the clinical relevance of targeting thrombin generation in managing atherosclerosis.

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