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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Artificial Macrocycles by Ugi Reaction and Passerini Ring Closure.

Eman M M Abdelraheem1,2, Katarzyna Kurpiewska3, Justyna Kalinowska-Tłuścik3

  • 1Department of Drug Design, University of Groningen , A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.

The Journal of Organic Chemistry
|September 7, 2016
PubMed
Summary

Researchers synthesized artificial macrocycles using Ugi and Passerini multicomponent reactions (MCRs). This study details the first intramolecular macrocyclization via a Passerini reaction, creating novel macrocyclic depsipeptides for drug discovery.

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