Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

5.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.9K
What is the Skeletal System?01:02

What is the Skeletal System?

58.5K
Overview
58.5K
Spongy Bone01:09

Spongy Bone

9.4K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
9.4K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.6K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.6K
Bone Remodeling01:40

Bone Remodeling

40.9K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.9K
Fractures: Bone Repair01:27

Fractures: Bone Repair

6.4K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cement Viscosity Is Associated With Aseptic Loosening After Primary Total Knee Arthroplasty: An Analysis of the American Joint Replacement Registry.

The Journal of arthroplasty·2026
Same author

Developing International Clinical Practice Guidelines: Lessons Learned in Achieving Global Consensus for the Association Research Circulation Osseous Guideline.

The Journal of arthroplasty·2026
Same author

Optimizing Anemia in Total Hip Arthroplasty: Experience With an Institutional Protocol.

The Journal of arthroplasty·2026
Same author

Commentary: Senescence-driven osteonecrosis of the femoral head in the elderly-A distinct pathophysiological entity.

Frontiers in medicine·2026
Same author

Nontraumatic Osteonecrosis of the Femoral Head: An International Evidence-Based Clinical Practice Guideline.

The Journal of arthroplasty·2026
Same author

Nontraumatic Osteonecrosis of the Femoral Head: An International Evidence-Based Clinical Practice Guideline.

The Journal of bone and joint surgery. American volume·2026

Related Experiment Video

Updated: Mar 15, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.5K

Osteonecrosis in Sickle Cell Disease.

Zan A Naseer1, Malick Bachabi1, Lynne C Jones1

  • 1From the Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, Maryland.

Southern Medical Journal
|September 7, 2016
PubMed
Summary

Sickle cell disease can cause osteonecrosis, particularly in the femoral head, leading to severe pain and joint issues. Total joint arthroplasty is the most effective treatment, requiring a multidisciplinary medical team.

More Related Videos

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

2.0K
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.6K

Related Experiment Videos

Last Updated: Mar 15, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.5K
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

2.0K
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.6K

Area of Science:

  • Orthopedics
  • Hematology
  • Pathophysiology

Background:

  • Osteonecrosis is a severe musculoskeletal complication of sickle cell disease, frequently impacting the femoral head.
  • The precise pathophysiology involves red blood cell sickling, vaso-occlusion, hypoxia, inflammation, and bone necrosis.
  • Untreated osteonecrosis leads to debilitating pain, functional loss, and degenerative joint disease.

Purpose of the Study:

  • To review the impact of osteonecrosis in sickle cell disease patients.
  • To discuss current understanding of pathophysiology and treatment options.

Main Methods:

  • Literature review of osteonecrosis in sickle cell disease.
  • Analysis of pathophysiology, clinical manifestations, and treatment outcomes.

Main Results:

  • Osteonecrosis commonly affects the femoral head in sickle cell disease patients.
  • Conservative treatments exist, but total joint arthroplasty is the most effective intervention.
  • A collaborative approach involving primary care, hematology, and orthopedic surgery is crucial.

Conclusions:

  • Effective management of osteonecrosis in sickle cell disease necessitates a coordinated multidisciplinary strategy.
  • Total joint arthroplasty offers the best outcome for patients with advanced disease.
  • Further research into pathophysiology may reveal novel therapeutic targets.