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Updated: Mar 15, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Perioperative Management in Sickle Cell Disease
1From the Department of Medicine, Division of Hematology/Oncology, University of Alabama at Birmingham.
Insights
Patients with sickle cell disease (SCD) often need surgery. Optimizing SCD care before and after surgery can reduce complications. Coordinating care with SCD specialists is crucial for better outcomes.
Area of Science:
- Hematology
- Surgical Management
- Anesthesiology
Background:
- Sickle cell disease (SCD) affects many patients requiring surgical intervention.
- Perioperative complications are common in SCD patients, linked to surgery or hemoglobinopathy.
- Effective management strategies are needed to mitigate surgical risks in SCD.
Purpose of the Study:
- To review the perioperative management of patients with sickle cell disease.
- To highlight strategies for reducing complication rates in SCD patients undergoing surgery.
- To emphasize the importance of multidisciplinary care coordination.
Main Methods:
- Literature review on perioperative care for sickle cell disease patients.
- Analysis of common surgical procedures in SCD patients (orthopedic, abdominal).
- Examination of factors contributing to perioperative complications.
Main Results:
- Perioperative complications are frequent in SCD patients.
- Preoperative optimization of SCD and postoperative care are key to reducing risks.
- Coordination with SCD specialists is recommended for both elective and emergent surgeries.
Conclusions:
- Careful perioperative management can significantly reduce complications in SCD patients.
- Multidisciplinary collaboration, including SCD specialists, is essential for optimal surgical outcomes.
- Proactive disease management is critical for patients with sickle cell disease undergoing surgery.
Abstract:
Many patients with sickle cell disease (SCD) will require surgical intervention during the course of their lifetime. Common surgeries include orthopedic and abdominal procedures. Perioperative complications occur commonly and can be related to the surgical procedure or the underlying hemoglobinopathy. The complication rate may be reduced by preoperative optimization of disease and careful attention to the patient in the postoperative period. This review examines the perioperative management of patients with SCD. For patients undergoing both elective and emergent surgery, attempts should be made to coordinate care with an SCD specialist.
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