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Related Experiment Videos

Drug-related headache.

H Askmark, P O Lundberg, S Olsson

    Headache
    |July 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    This study identified drugs commonly linked to headaches and migraines. Researchers found that vasodilatation and fluid retention may cause drug-related headaches, though mechanisms for some drugs remain unclear.

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    Area of Science:

    • Pharmacovigilance
    • Neurology
    • Drug Safety

    Background:

    • Adverse drug reactions can manifest as neurological symptoms, including headaches and migraines.
    • Understanding drug-induced neurological events is crucial for patient safety and effective treatment.

    Purpose of the Study:

    • To survey drug-associated headache, migraine, aggravated migraine, and intracranial hypertension.
    • To identify frequently implicated drugs and explore potential underlying mechanisms.

    Main Methods:

    • Analysis of 10,506 reports from the WHO Collaboration Centre for International Drug Monitoring.
    • Inclusion of data from five countries.

    Main Results:

    • Top drugs associated with headache: indomethacin, nifedipine, cimetidine, atenolol, trimethoprim-sulphamethoxazole, zimeldine, glyceryl trinitrate, isosorbide dinitrate, zomepirac, and ranitidine.

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  • Oral contraceptives were frequently implicated in migraine.
  • Tetracyclines, isotretinoin, and trimethoprim-sulphamethoxazole were most often linked to intracranial hypertension.

    • Conclusions:

    • Vasodilatation and fluid retention are potential mechanisms for drug-related headaches.
    • Mechanisms for headache causation by certain frequently reported drugs are yet to be elucidated.