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Updated: Mar 15, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Management of proliferative lupus nephritis
Jose M Monroy Trujillo1, Derek M Fine
1Division of Nephrology, Johns Hopkins Hospital, Baltimore, MD, USA - jmonroy2@jhmi.edu.
Abstract:
Kidney abnormalities are present in up to 60% of patients with systemic lupus. Proliferative lupus nephritis is one of the most serious manifestation and requires rapid recognition and treatment. Kidney biopsy plays an essential role in the management and prognosis of proliferative lupus nephritis. Treatment includes and induction phase with systemic steroids and antiproliferative therapy. This is followed by a maintenance phase to prevent the risk of relapses. Cytotoxic therapy carries significant side effects and complications. Further research is needed to establish the role of biologics in the management of proliferative lupus nephritis.
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