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EANO guidelines for the diagnosis and treatment of meningiomas

Roland Goldbrunner1, Giuseppe Minniti2, Matthias Preusser3

  • 1Center of Neurosurgery, Department of General Neurosurgery, University of Cologne, Cologne, Germany.

The Lancet. Oncology
|September 7, 2016
PubMed

Insights

Meningiomas, common brain tumors, have limited evidence for treatment guidelines. The European Association of Neuro-Oncology (EANO) developed evidence-based recommendations for diagnosis and management of these intracranial tumors.

Area of Science:

  • Neuro-oncology
  • Neurosurgery
  • Radiation Oncology

Background:

  • Meningiomas are the most frequent primary intracranial tumors.
  • Limited high-level evidence exists for meningioma diagnosis and treatment recommendations compared to other brain tumors.
  • The European Association of Neuro-Oncology (EANO) established a task force to address this gap.

Purpose of the Study:

  • To assess the scientific literature on meningiomas.
  • To develop evidence-based recommendations for the diagnosis and treatment of meningiomas for health professionals.
  • To provide a framework for managing these common intracranial tumors.

Main Methods:

  • Comprehensive review of the scientific literature on meningiomas.
  • Expert consensus and evidence grading by the EANO meningioma task force.
  • Formulation of clinical recommendations based on the assessed evidence.

Main Results:

  • Magnetic Resonance Imaging (MRI) is crucial for provisional meningioma diagnosis.
  • Definitive diagnosis requires surgical tissue for histological classification, grading, and molecular profiling.
  • Observation is often the best approach for elderly patients; surgical resection or radiotherapy are standard treatments when necessary.
  • Novel treatment strategies combining surgery and radiotherapy, as well as experimental pharmacotherapies, are under investigation.

Conclusions:

  • Evidence-based recommendations for meningioma diagnosis and treatment are now available.
  • Management strategies include observation, surgery, radiotherapy, and emerging pharmacotherapies.
  • Further research is needed to advance treatment options, particularly for refractory meningiomas.

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