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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
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Mantle cell lymphoma presenting with spontaneous splenic rupture
Yukako Maeda-Sakagami1, Yasuhiro Tanaka, Yusuke Koba
1Department of Clinical Immunology and Hematology, Nishi-Kobe Medical Center.
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|September 8, 2016
Summary
Spontaneous splenic rupture can be a rare initial sign of mantle cell lymphoma, a type of blood cancer. Prompt diagnosis and treatment with chemotherapy and stem cell transplant led to a complete remission in this patient.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin lymphoma.
- Spontaneous splenic rupture is an uncommon but critical presentation of hematological malignancies.
Observation:
- A 48-year-old male presented with acute abdominal pain and nausea, found to have splenic rupture with intra-abdominal bleeding.
- Histopathology revealed the spleen infiltrated by abnormal tumor cells, leading to a diagnosis of MCL.
- Staging via PET-CT confirmed stage IVA disease involving bone marrow and ileum.
Findings:
- The patient received rituximab plus hyper-CVAD/MA chemotherapy (R-hyper-CVAD/MA), achieving complete response after two courses.
- Following four courses of R-hyper-CVAD/MA, he underwent high-dose chemotherapy and autologous peripheral blood stem cell transplantation (auto-PBSCT).
- The patient remains alive and disease-free, highlighting treatment efficacy.
Implications:
- This case underscores the importance of considering hematological malignancies in patients presenting with spontaneous splenic rupture.
- Early recognition and multidisciplinary management are crucial for favorable outcomes in MCL.
- This report adds to the limited literature on MCL presenting as spontaneous splenic rupture.
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