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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Parkinson's Disease: Treatment01:24

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Related Experiment Video

Updated: Mar 15, 2026

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies
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iPS cell therapy for Parkinson's disease.

Jun Takahashi1

  • 1Center for iPS Cell Reserach and Application, Kyoto University.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|September 8, 2016
PubMed
Summary

Stem cell therapy for Parkinson's disease (PD) aims to restore dopamine levels. Induced pluripotent stem cells (iPSCs) offer a promising alternative for generating dopaminergic neurons for transplantation.

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons.
  • Current stem cell therapy for PD focuses on replacing lost neurons and restoring dopamine release.
  • Fetal ventral-midbrain cells have shown potential in alleviating PD symptoms.

Purpose of the Study:

  • To explore induced pluripotent stem cells (iPSCs) as a viable donor cell source for Parkinson's disease therapy.
  • To develop a safe and efficient method for isolating dopaminergic (DA) neuron progenitors for transplantation.
  • To evaluate the potential of iPSC-derived DA neurons in reconstructing neural circuits and relieving PD symptoms.

Main Methods:

  • Development of a protocol to generate dopaminergic (DA) neurons from induced pluripotent stem cells (iPSCs).

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  • Isolation of DA neuron progenitors as a specific donor cell population.
  • Assessment of the safety and efficiency of the transplantation method.

    • Main Results:

    • Induced pluripotent stem cells (iPSCs) possess self-renewal and pluripotency, making them suitable for generating dopaminergic (DA) neurons.
    • Human embryonic stem cells (ESCs) have demonstrated functionality in PD models in rats and monkeys.
    • A novel method for isolating DA neuron progenitors enables safe and efficient transplantation.

    Conclusions:

    • Induced pluripotent stem cells (iPSCs) represent a promising alternative to fetal cells for Parkinson's disease (PD) treatment.
    • The developed method for isolating dopaminergic (DA) neuron progenitors ensures safe and effective cell transplantation.
    • This approach holds potential for reconstructing synapse formation and restoring dopamine levels in PD patients.