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Updated: Mar 15, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
[Effect of acitretin and methotrexate on treatment of severe plaque psoriasis]
Panpan Liu1, Yehong Kuang1, Jianglin Zhang1
1Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Objective:
To evaluate effects of acitretin and methotrexate on treatment of severe plaque psoriasis.
Methods:
A total of 54 patients were treated with either acitretin (32 patients; 30 mg per day) or methotrexate (22 patients; 15 mg per week) for 8 weeks. The therapeutic effects of the two drugs were evaluated according to the psoriasis area and severity index (PASI).
Results:
After 8 weeks of treatment, the score of PASI decreased in both the acitretin group and the methotrexate group (P<0.001). However, there was no significant differences neither in the percentage reduction in the PASI score nor in PASI response rate between the two groups (P>0.05).
Conclusion:
Acitretin and methotrexate exert similar therapeutic effect in severe plaque psoriasis.
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