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Microarray-Based Comparative Genomic and Transcriptome Analysis of Borrelia burgdorferi.

Radha Iyer1, Ira Schwartz2

  • 1Department of Microbiology and Immunology, New York Medical College, School of Medicine, Valhalla, NY 10595, USA. radha_iyer@nymc.edu.

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|September 8, 2016
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Summary

This review summarizes microarray studies on Borrelia burgdorferi, the Lyme disease bacterium. It highlights how gene expression regulation helps the bacterium adapt to tick and mammalian hosts, revealing interconnected signaling pathways.

Keywords:
Borrelia burgdorferiLyme diseasemicroarraytranscriptional regulatorstranscriptome

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Area of Science:

  • Microbiology
  • Genomics
  • Transcriptomics

Background:

  • Borrelia burgdorferi, the causative agent of Lyme disease, cycles between tick vectors and mammalian hosts.
  • Adaptation to diverse environmental conditions necessitates precise gene expression control.

Purpose of the Study:

  • To review and synthesize findings from over 25 microarray analyses of Borrelia burgdorferi.
  • To identify transcriptional regulators crucial for gene expression modulation in tick and mammalian environments.
  • To explore the overlap in regulatory circuits between tick and mammalian phases of the enzootic cycle.

Main Methods:

  • Comparative analysis of published microarray expression profiling studies.
  • Identification of composite gene lists for differentially expressed genes in tick and mammalian environments.
  • Exploration of regulatory circuit overlap.

Main Results:

  • Microarray analyses have significantly advanced the understanding of Borrelia burgdorferi transcriptional regulation.
  • Differential gene expression patterns were identified between tick and mammalian environments.
  • Interplay among signaling pathways governing tick feeding and mammalian adaptation was observed.

Conclusions:

  • Transcriptional regulators play key roles in Borrelia burgdorferi adaptation to its hosts.
  • Distinct yet interconnected signaling pathways are active during the tick and mammalian stages of the Lyme disease cycle.