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Karyotyping

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Updated: Mar 15, 2026

Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants

Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

SNPs Array Karyotyping in Non-Hodgkin Lymphoma.

Maryam Etebari¹, Mohsen Navari², Pier Paolo Piccaluga³

¹Department of Experimental, Diagnostic, and Specialty Medicine; Hematopathology Unit, S. Orsola-Malpighi Hospital, Bologna 40138, Italy. maryam.etebari@gmail.com.

Microarrays (Basel, Switzerland)

|September 8, 2016

Summary

Single nucleotide polymorphism (SNP) arrays offer a sensitive method for detecting chromosomal aberrations in non-Hodgkin lymphomas. This review updates knowledge on genomic complexity in these cancers using SNP array data.

Keywords:

genetic aberrations non-Hodgkin lymphoma single nucleotide polymorphism (SNP) array

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Last Updated: Mar 15, 2026

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Area of Science:

Genomics
Oncology
Molecular Biology

Background:

Traditional methods for detecting chromosomal aberrations had limitations in sensitivity and required prior genomic region knowledge.
Single nucleotide polymorphism (SNP) arrays have enabled comprehensive genome screening for chromosomal abnormalities.

Purpose of the Study:

To review and update the understanding of genomic complexity in non-Hodgkin lymphomas.
To highlight the utility of SNP arrays in identifying chromosomal aberrations.

Main Methods:

Review of studies utilizing single nucleotide polymorphism (SNP) arrays.
Analysis of genomic data from various non-Hodgkin lymphoma subtypes.

Main Results:

SNP arrays facilitate the detection of copy number variants, DNA amplifications, deletions, and loss of heterozygosity.
Genomic complexity in key non-Hodgkin lymphoma subtypes has been elucidated through SNP array analysis.

Conclusions:

SNP arrays are a powerful tool for global genome screening in hematological malignancies.
Advancements in SNP array technology have significantly improved the characterization of non-Hodgkin lymphoma genomic landscapes.