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Related Experiment Video

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Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

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Published on: March 21, 2021

Lung function, inflammation and cardiovascular mortality in Africans.

Yolandi Breet¹, Aletta E Schutte^1,2, Hugo W Huisman^1,2

¹Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.

European Journal of Clinical Investigation

|September 8, 2016

Summary

In black South Africans, reduced forced vital capacity (FVC) predicts mortality. This association may be linked to inflammation, highlighting lung function

Keywords:

African South Africa death pulmonary function

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Area of Science:

Cardiology
Pulmonology
Epidemiology

Background:

The link between impaired lung function and cardiovascular outcomes is established in Western populations.
Systemic inflammation from the lungs may drive this association.
Increased inflammatory markers in African populations warrant further investigation.

Purpose of the Study:

To determine if lung function predicts all-cause and cardiovascular mortality in black South Africans.
To assess the role of inflammatory markers in this relationship.

Main Methods:

A five-year follow-up of 1442 black South Africans (PURE study).
Spirometry, cardiovascular, and metabolic measures were collected.
All-cause and cardiovascular mortality served as endpoints.

Main Results:

Univariate analysis showed both FEV1 and FVC predicted mortality.
Multivariate analysis revealed FVC independently predicted cardiovascular mortality, even with C-reactive protein (CRP) considered.
The predictive significance of FVC was lost when CRP was replaced by interleukin-6.

Conclusions:

Forced vital capacity (FVC), not FEV1, is a significant predictor of all-cause and cardiovascular mortality in black South Africans.
Inflammation may mediate the relationship between FVC and mortality.