Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Myasthenia Gravis: Diagnostic Tests

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Use of Durable Medical Equipment in COURAGE-ALS, a Phase 3, Multicentre, Randomized Clinical Trial for ALS.

Muscle & nerve·2026

Same author

Pridopidine treatment in ALS: subgroup analyses from the HEALEY ALS Platform trial.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2025

Same author

Participant, site personnel and sponsor perspectives on decentralized trial features in COURAGE-ALS: a randomized clinical trial.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2025

Same author

Hospitalizations as an outcome measure in COURAGE-ALS.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2025

Same author

Application of the ENCALS predictive survival model in assessing the effect of the 24/44 inclusion criteria in FORTITUDE-ALS.

Journal of neuromuscular diseases·2025

Same author

Reldesemtiv in Amyotrophic Lateral Sclerosis: Results From the COURAGE-ALS Randomized Clinical Trial.

JAMA neurology·2025

Same journal

Contemporary surgical strategies for resection of intracranial gliomas.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026

Same journal

FGF17 synergistically targets neuronal survival and oligodendrogenesis to restore stroke deficits.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026

Same journal

Sotagliflozin improves cognitive deficits and attenuates neuroinflammation of Alzheimer's disease.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026

Same journal

Neurological complications of current and emerging CAR-T cell therapies.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026

Same journal

Hemodynamics Beyond Ischemic Zone Underlies Early Neurological Deterioration in Minor Stroke with Large Vessel Occlusion.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026

Same journal

Nervonic acid and the long arc of therapeutic hope in X-linked adrenoleukodystrophy.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 15, 2026

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

Strength Testing in Motor Neuron Diseases.

Jeremy M Shefner¹

¹Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, 85013, USA. Jeremy.shefner@dignityhealth.org.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics

|September 8, 2016

Summary

This summary is machine-generated.

Accurate measurement of limb muscle strength is crucial for motor neuron disease trials. Quantitative strength measures are reliable indicators of disease progression and therapeutic impact.

Keywords:

Hand held dynamometry Manual muscle testing Motor neuron disease Spinal muscular atrophy TQNE

More Related Videos

Measuring Neuromuscular Junction Functionality

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

Published on: June 15, 2018

Related Experiment Videos

Last Updated: Mar 15, 2026

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

Measuring Neuromuscular Junction Functionality

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

Published on: June 15, 2018

Area of Science:

Neurology
Rehabilitation Medicine
Biomedical Engineering

Background:

Muscle strength loss is a primary characteristic of motor neuron diseases (MNDs).
Functional decline in MNDs, including respiratory and mobility issues, is largely attributed to diminished muscle strength.
Accurate strength measurement is vital for assessing therapeutic efficacy in clinical trials.

Purpose of the Study:

To review qualitative and quantitative methods for measuring limb muscle strength in motor neuron diseases.
To examine the utility and limitations of various strength measurement techniques.
To highlight the importance of reliable strength assessment in therapeutic trials for MNDs.

Main Methods:

Review of existing literature on qualitative and quantitative strength measurement techniques.
Analysis of the reproducibility, linearity, and sensitivity of different measurement approaches.
Examination of data from clinical trials involving amyotrophic lateral sclerosis (ALS), spinobulbar muscular atrophy (SBMA), and spinal muscular atrophy (SMA).

Main Results:

Qualitative strength measurements lack reproducibility and linearity, making them inadequate for tracking disease progression or therapeutic effects.
Quantitative strength measurements, with proper training and reliability testing, are reliable and sensitive indicators.
Quantitative measures have shown potential therapeutic effects in ALS and SBMA and are feasible in pediatric SMA.

Conclusions:

Quantitative limb muscle strength measurement is essential for evaluating disease progression and therapeutic interventions in motor neuron diseases.
Reliable quantitative methods are critical for the successful design and execution of clinical trials for MNDs.
The careful application of quantitative strength assessment provides valuable insights into disease dynamics and treatment outcomes.