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Cryptococcal osteomyelitis of the skull in a liver transplant patient

Aviv V Pudipeddi1, Ken Liu1, Geoffrey F Watson2

  • 1AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, NSW, Australia.

Transplant Infectious Disease : an Official Journal of the Transplantation Society
|September 8, 2016
PubMed

Insights

This case study details a rare instance of isolated cryptococcal osteomyelitis in a liver transplant recipient. The infection, caused by Cryptococcus neoformans, affected the scalp and bone, presenting uniquely without central nervous system involvement.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Transplant Surgery

Background:

  • Cryptococcus neoformans is an opportunistic fungus causing significant morbidity and mortality in immunocompromised individuals.
  • Liver transplant recipients are particularly susceptible to opportunistic infections due to long-term immunosuppression.

Observation:

  • A liver transplant recipient presented with headache and a scalp lump following minor head trauma.
  • Clinical examination and imaging revealed osteomyelitis of the scalp bone.

Findings:

  • The osteomyelitis was confirmed to be caused by Cryptococcus neoformans.
  • There was no evidence of central nervous system (CNS) involvement or systemic dissemination of the fungus.
  • This represents the first reported case of isolated cryptococcal osteomyelitis in a liver transplant recipient.

Implications:

  • Highlights the potential for unusual presentations of cryptococcosis in transplant patients.
  • Underscores the importance of considering fungal infections in immunocompromised hosts with localized symptoms.
  • May inform diagnostic and treatment strategies for cryptococcal osteomyelitis in similar patient populations.
Keywords:
Cryptococcosisfungal infectionimmunosuppressed hostliver transplantationopportunistic infectionosteomyelitis

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