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HPLC studies on the degradation profiles of glucose 5% solutions subjected to heat sterilization in a
A P Cook1, T M MacLeod, J D Appleton
1Area Pharmaceutical Laboratory, Ninewells Hospital, Dundee, U.K.
Journal of Clinical Pharmacy and Therapeutics
|June 1, 1989
Abstract:
A practically useful relationship between degradation and F0 at various temperatures is given. This may be of value for identifying the most suitable sterilization conditions for a number of glucose products and other pharmaceuticals. It was found that autoclaving at a high temperature to a low final F0 value gave the maximum product integrity.