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Identification of 12 Cases of Acute Measles Encephalitis Without Rash
Sai-Zhen Zeng1, Bing Zhang1, Yan Zhang2
1Hunan Provincial People's Hospital, Changsha.
Abstract:
Twelve cases of acute measles encephalitis without rash were identified from October 2011 to July 2013 in Changsha city, China; 5 were found to be genotype H1 and 2 were B3. Our data suggest that screening for measles virus is necessary in children with viral encephalitis, to eliminate the disease.
Insights
Acute measles encephalitis can occur without a rash. Screening children with viral encephalitis for measles virus is crucial for disease elimination.
Area of Science:
- Neurology
- Virology
- Pediatrics
Background:
- Measles encephalitis is a severe neurological complication of measles infection.
- Typical presentation includes fever, rash, and neurological symptoms.
Observation:
- A study identified twelve cases of acute measles encephalitis presenting without a rash in Changsha, China.
- These cases occurred between October 2011 and July 2013.
Findings:
- Five of the identified cases were associated with measles virus genotype H1.
- Two cases were linked to genotype B3.
- The absence of rash in these cases highlights a diagnostic challenge.
Implications:
- The findings underscore the necessity of including measles virus screening in the diagnostic workup for children presenting with viral encephalitis, even in the absence of a rash.
- Early identification and isolation can aid in preventing measles transmission and managing encephalitis effectively.
