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Fully automatic input function determination program for simple noninvasive (123)I-IMP microsphere cerebral blood

Kosuke Yamashita1, Yoshikazu Uchiyama2, Asato Ofuji3

  • 1Graduate School of Health Sciences, Kumamoto University, 4-24-1 Kuhonji, Chuo-ku, Kumamoto 862-0796, Japan; Fujifilm RI Pharma Co. Ltd., Kyobashi 14-1 2-chome, Chuo-ku, Tokyo 104-0031, Japan.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
|September 8, 2016
PubMed
Summary

A new fully automatic program enhances the Simple Noninvasive microsphere (SIMS) method for regional cerebral blood flow (rCBF) analysis. This innovation improves accuracy and significantly reduces examination time in nuclear medicine.

Keywords:
(123)I-IMP SPECTFully automatic programNoninvasive quantitative measurementsrCBF

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Area of Science:

  • Nuclear Medicine
  • Medical Imaging Analysis
  • Cerebrovascular Physiology

Background:

  • The Simple Noninvasive microsphere (SIMS) method analyzes regional cerebral blood flow (rCBF) using (123)I-IMP microspheres.
  • Current SIMS analysis requires manual region of interest (ROI) setting for input function determination, impacting repeatability and reproducibility.
  • A fully automatic ROI setting algorithm is needed to guarantee the reliability of SIMS-based rCBF analysis.

Purpose of the Study:

  • To develop a fully automatic input function determination program for the SIMS method.
  • To confirm the clinical usefulness and efficiency of the developed automatic program.

Main Methods:

  • Developed an automatic input function determination program using image phase analysis of chest RI angiograms.
  • The program incorporates two ROI setting algorithms for the pulmonary artery (PA) and lung regions.
  • Compared rCBF measurements in 34 patients using the automatic method versus manual ROI setting.

Main Results:

  • Input functions determined by the automatic and manual methods showed approximate equality.
  • A strong correlation (r=0.96, p<0.01) was observed between rCBF values obtained by both methods.
  • Automatic SIMS analysis reduced total examination time from 20-30 minutes to 1-2 minutes.

Conclusions:

  • The developed fully automatic input function determination program is clinically useful for the SIMS method.
  • The program ensures the repeatability and reproducibility of rCBF analysis.
  • This automation significantly improves throughput in nuclear medicine examinations.