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Role of sleep quality in the metabolic syndrome
Dorit Koren1, Magdalena Dumin2, David Gozal3
1Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, Department of Medicine; Section of Pediatric Sleep Medicine.
Abstract:
Emerging evidence has assigned an important role to sleep as a modulator of metabolic homeostasis. The impact of variations in sleep duration, sleep-disordered breathing, and chronotype to cardiometabolic function encompasses a wide array of perturbations spanning from obesity, insulin resistance, type 2 diabetes, the metabolic syndrome, and cardiovascular disease risk and mortality in both adults and children. Here, we critically and extensively review the published literature on such important issues and provide a comprehensive overview of the most salient pathophysiologic pathways underlying the links between sleep, sleep disorders, and cardiometabolic functioning.
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