Effects of estrogen on low density lipoprotein metabolism in males. Short-term and long-term studies during hormonal treatment of prostatic carcinoma
- M Eriksson 1, L Berglund , M Rudling , P Henriksson , B Angelin
- 1Department of Medicine, Karolinska Institute, Huddinge, Sweden.
- 0Department of Medicine, Karolinska Institute, Huddinge, Sweden.
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View abstract on PubMed
Summary
This summary is machine-generated.Estrogen therapy significantly boosts the breakdown of low-density lipoprotein (LDL) in men with prostate cancer. This leads to lower LDL cholesterol levels, even with increased LDL production, suggesting enhanced liver receptor activity.
Area Of Science
- Endocrinology
- Cardiovascular Metabolism
- Oncology
Background
- Estrogen's role in lipid metabolism is complex and sex-dependent.
- Understanding estrogen's impact on low-density lipoprotein (LDL) metabolism is crucial, particularly in male patients undergoing treatment.
Purpose Of The Study
- To investigate the effects of estrogen treatment on LDL metabolism in males with metastatic prostatic carcinoma.
- To quantify changes in LDL fractional catabolic rate (FCR) and LDL cholesterol levels during estrogen therapy.
Main Methods
- Studied six males with metastatic prostatic carcinoma before and during estrogen therapy.
- Utilized autologous 125I-LDL to calculate FCR from plasma radioactivity elimination curves and urine/plasma radioactivity ratios.
- Performed repeated studies after 3-6 months of treatment and conducted tissue culture studies on LDL receptor affinity.
Main Results
- Within 1-2 days of estrogen therapy, FCR increased by 20% and LDL cholesterol decreased by 16%.
- After 3-6 months, FCR nearly doubled, and LDL cholesterol reduced by 34%, despite a 29% increase in LDL synthesis.
- LDL isolated from patients on long-term estrogen therapy showed reduced receptor affinity.
Conclusions
- Pharmacological doses of estrogen profoundly increase LDL catabolism in males.
- Hypothesized that increased hepatic LDL receptor expression mediates enhanced LDL catabolism.
- Estrogen therapy results in LDL particles with lower receptor affinity, contributing to reduced plasma LDL levels.
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