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Infertility in men with inflammatory bowel disease
1Takeshi Shin, Hiroshi Okada, Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama 343-8555, Japan.
World Journal of Gastrointestinal Pharmacology and Therapeutics
|September 8, 2016
Summary
Inflammatory bowel disease (IBD) can impact male fertility through active inflammation, lifestyle factors, and treatments. Sulfasalazine is a key medication affecting male fertility, while other treatments have limited data.
Area of Science:
- Gastroenterology
- Reproductive Medicine
- Urology
Background:
- Inflammatory bowel disease (IBD) primarily affects young adults, making fertility a significant concern.
- Reproductive health in men with IBD is under-researched compared to women.
- Understanding male fertility issues in IBD is crucial for comprehensive patient management.
Purpose of the Study:
- To systematically review the existing literature on the effects of IBD and its treatments on male fertility.
- To identify factors contributing to infertility in men with IBD.
- To discuss potential treatment options for fertility-related issues.
Main Methods:
- Systematic literature search on PubMed using terms like "IBD AND male infertility".
- Inclusion of relevant references from review articles.
- Analysis of identified studies focusing on IBD, male infertility, and treatment effects.
Main Results:
- Active inflammation, poor nutrition, alcohol, smoking, medications, and surgery are linked to male infertility in IBD.
- Proctocolectomy with ileal pouch-anal anastomosis may cause sexual dysfunction.
- Sulfasalazine reversibly reduces male fertility; other medications have limited evidence of significant impact.
Conclusions:
- Male fertility in IBD is influenced by disease activity, lifestyle, and specific treatments.
- Further research is needed on the effects of IBD medications on male fertility and pregnancy outcomes.
- Informing patients about potential risks of paternal drug exposure is essential.
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