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Suitable bone markers assessing bone status in patients with both coronary artery disease and diabetes

Zhila Maghbooli1, Solaleh Emamgholipour2, Arash Hossein-Nezhad3

  • 1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Journal of Diabetes and Metabolic Disorders
|September 8, 2016
PubMed

Insights

Bone turnover markers osteocalcin (OC) and carboxy-terminal collagen crosslinks (CTX) are lower in coronary artery disease (CAD) patients with type 2 diabetes (T2DM). These markers may be useful for managing CAD patients with diabetes.

Area of Science:

  • Cardiology
  • Endocrinology
  • Bone Metabolism

Background:

  • Coronary artery disease (CAD) and type 2 diabetes (T2DM) are significant health concerns.
  • Investigating bone turnover markers in CAD patients with and without T2DM is crucial for understanding disease interplay.

Purpose of the Study:

  • To compare bone turnover markers (osteocalcin, P1NP, CTX) in CAD patients with and without T2DM.
  • To assess the relationship between bone markers, metabolic factors, and CAD status.

Main Methods:

  • Cross-sectional study of 45 patients undergoing heart surgery.
  • Categorized participants into CAD (n=33) and non-CAD (n=12) groups.
  • Analyzed serum levels of OC, P1NP, CTX, 25(OH) vitamin D3, PTH, and metabolic factors.

Main Results:

  • No significant difference in bone markers between CAD and non-CAD groups.
  • FBG showed an inverse correlation with OC in CAD patients.
  • OC and CTX levels were significantly lower in CAD patients with T2DM compared to those without diabetes.

Conclusions:

  • Osteocalcin (OC) and carboxy-terminal collagen crosslinks (CTX) show potential as bone turnover markers in CAD patients with T2DM.
  • Further research is needed to confirm the clinical utility of these markers in managing diabetes and CAD.
Abstract

Keywords:
Bone markerBone turnoverCTXCoronary artery diseaseOCP1NPType 2 diabetes mellitus

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