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Synthetic Studies toward the C14-C29 Fragment of Mirabalin
Johan Cornil1, Pierre-Georges Echeverria2, Sébastien Reymond1
1Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231, ESPCI Paris/CNRS/PSL Research University , 10 rue Vauquelin 75231 Cedex 05 Paris, France.
Organic Letters
|September 8, 2016
Abstract:
A convergent synthesis of one isomer of the C14-C29 fragment of mirabalin is disclosed. The key steps include a Marshall allenylation, a Mukaiyama aldol reaction and a Crimmins aldolization, which allow the control of 10 out of 25 stereogenic centers present in the molecule.
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