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Updated: Mar 15, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
Published on: March 3, 2021
Induced Hypothermia in Neurocritical Care: A Review
1Questions or comments about this article may be directed to Courtney J. Cook, ACNP DNP, at courtney.j.cook@vanderbilt.edu. She is an Assistant Professor of Nursing, Vanderbilt School of Nursing, Nashville, TN. No funding or financial resources are associated with the content of this article. There is no financial relationship with the Arctic Sun Corporation.
Abstract:
Induced hypothermia (IH) continues to become a more prevalent treatment modality in neurocritical care. Reducing core temperature has been shown to protect brain tissue during injury and disease. IH has been particularly beneficial in the medical management of refractory intracranial hypertension and malignant cerebral edema. These pathologies are often the result of diffuse cerebral edema after traumatic brain injury, malignant ischemic stroke, or intracerebral hemorrhage. Although there are many benefits to IH, it is not without complications. Chief among these is shivering, which decreases oxygen delivery to brain tissue, increases metabolic demands, and consequently reduces nutrient delivery. This article will review indications for IH administration, methods of providing IH, nursing responsibilities, and identifying and/or managing complications.

