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Polyethylene glycol plus ascorbic acid for bowel preparation in chronic kidney disease
Jae Min Lee1, Bora Keum, In Kyung Yoo
1Division of Gastroenterology and Hepatology Division of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seongbuk-gu, Seoul, 02841, Korea.
Medicine
|September 8, 2016
Summary
Polyethylene glycol plus ascorbic acid is safe for bowel prep in patients with chronic kidney disease. This bowel cleansing agent did not affect renal function and was better tolerated than higher volume solutions.
Area of Science:
- Nephrology
- Gastroenterology
Background:
- Safety of polyethylene glycol plus ascorbic acid in renal insufficiency is not well-established.
- High-dose ascorbic acid may cause hyperoxaluria, leading to renal complications.
Purpose of the Study:
- To evaluate the safety and efficacy of polyethylene glycol plus ascorbic acid in patients with chronic kidney disease.
- To compare bowel preparation outcomes between 2 L polyethylene glycol plus ascorbic acid and 4 L polyethylene glycol.
Main Methods:
- Retrospective review of prospectively collected colonoscopy data.
- Patients with impaired renal function were divided into two groups: 2 L polyethylene glycol plus ascorbic acid (n=61) and 4 L polyethylene glycol (n=80).
- Safety was assessed by comparing pre- and post-cleansing laboratory findings, including estimated glomerular filtration rate (eGFR).
Main Results:
- No significant differences in laboratory findings were observed between the two groups.
- Administration of either bowel preparation did not influence eGFR in patients with chronic kidney disease.
- The 2 L polyethylene glycol plus ascorbic acid group reported better tolerance and acceptability.
Conclusions:
- 2 L polyethylene glycol plus ascorbic acid is a safe and well-tolerated bowel preparation option for patients with impaired renal function undergoing colonoscopy.
- This regimen does not adversely affect renal function in patients with chronic kidney disease.
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