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TLR4 polymorphism and periodontitis susceptibility: A meta-analysis.
Su-Han Jin1, Xiao-Yan Guan, Wen-Hong Liang
1Stomatological Hospital Affiliated to Zunyi Medical College School of Stomatology, Zunyi Medical University Special Key Laboratory of Oral Diseases Research, Higher Education Institution, Zunyi, Guizhou Province, China.
Medicine
|September 8, 2016
Summary
This meta-analysis found Toll-like receptor 4 (TLR4) C>G polymorphism is associated with chronic periodontitis in Asian populations. This genetic link may be inherited recessively, warranting further investigation.
Area of Science:
- Genetics
- Immunology
- Periodontology
Background:
- Previous studies on Toll-like receptor 4 (TLR4) polymorphism and periodontitis susceptibility yielded conflicting results.
- Research primarily focused on Caucasian populations, specifically TLR4-299A>G or TLR4-399C>T variants.
Purpose of the Study:
- To reassess the association between TLR4 polymorphism and periodontitis susceptibility.
- To update existing meta-analyses on this topic.
Main Methods:
- A comprehensive literature search was conducted across multiple electronic databases (CNKI, PubMed, Embase) and hand-searched references.
- 18 studies, involving 2453 healthy controls and 3449 periodontitis patients (CP and AP), were included.
- Data analysis utilized STATA software (version 12.0) with Newcastle-Ottawa Scale for quality assessment.
Main Results:
- A significant association was found between the TLR4C>G (rs7873784) allele and chronic periodontitis (CP) in Asian individuals.
- The recessive model for TLR4C>G showed a significant association (OR = 0.66, 95% CI = 0.49-0.89).
- No significant associations were detected for other TLR4 polymorphisms with periodontitis susceptibility in overall or subgroup analyses.
Conclusions:
- The TLR4C>G (rs7873784) allele is associated with chronic periodontitis in Asian populations.
- This association may be inherited recessively.
- Further research is recommended to confirm the link between TLR4C>G and chronic periodontitis.
