Related Experiment Video

Updated: Mar 15, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

10.7K

Recent Advances in Oncogenic Roles of the TRPM7 Chanzyme

Mathieu Gautier1, Marianne Perrière, Michael Monet

  • 1University of Picardie Jules Verne, F-80039, France.

Current Medicinal Chemistry
|September 9, 2016
PubMed

Insights

Transient Receptor Potential Melastatin-related 7 (TRPM7) channels are implicated in cancer progression. This review explores TRPM7's dual role in cation signaling and kinase function, highlighting its potential as a therapeutic target in malignancies.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Transient Receptor Potential Melastatin-related 7 (TRPM7) is a bifunctional protein with both ion channel and kinase activities.
  • TRPM7 plays physiological roles in magnesium homeostasis, cell survival, and motility.
  • Aberrant TRPM7 expression is observed in various cancers, correlating with poor prognosis in breast cancer.

Purpose of the Study:

  • To review the multifaceted role of TRPM7 channels in cancer progression.
  • To elucidate the distinct contributions of TRPM7's cation signaling and kinase functions in malignancies.
  • To discuss emerging pharmacological strategies targeting TRPM7 for cancer therapy.

Main Methods:

  • Literature review of studies investigating TRPM7 in cancer.
  • Analysis of TRPM7's channel activity (ion transport) and kinase activity (protein phosphorylation).
  • Examination of TRPM7's impact on cancer cell hallmarks like proliferation, migration, and invasion.

Main Results:

  • TRPM7 channel activity influences cation influx, affecting cellular processes critical for cancer.
  • TRPM7 kinase phosphorylates substrates like myosin, regulating cell tension and motility in cancer cells.
  • TRPM7 cleavage by caspase contributes to apoptosis signaling pathways relevant to cancer.

Conclusions:

  • TRPM7 plays a significant role in cancer progression through both its channel and kinase functions.
  • Understanding the specific mechanisms of TRPM7 in cancer is crucial for developing targeted therapies.
  • Pharmacological inhibitors of TRPM7 show promise as a novel approach for cancer treatment.

More Related Videos

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

15.8K
Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

10.0K

Related Concept Videos

Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
8.0K
Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
34.7K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.6K
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
88.3K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K