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Related Concept Videos

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Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
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Hearing01:31

Hearing

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When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
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Related Experiment Video

Updated: Mar 15, 2026

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
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Serum Uric Acid Relation for Hearing Threshold Shift.

Hui-Fang Yang1,2, Tung-Wei Kao1,2,3, Tao-Chun Peng1

  • 1Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan.

Clinical and Experimental Otorhinolaryngology
|September 9, 2016
PubMed
Summary
This summary is machine-generated.

Elevated serum uric acid (UA) levels are inversely associated with better hearing thresholds in U.S. adults. This suggests a potential link between uric acid and auditory health, warranting further investigation into hearing health.

Keywords:
AntioxidantsHearingNeuroprotectionUric Acid

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Area of Science:

  • Otolaryngology
  • Biochemistry
  • Epidemiology

Background:

  • Serum uric acid (UA) is implicated in various diseases via oxidative stress.
  • Research on the association between UA and hearing thresholds is limited.
  • Understanding this relationship is crucial for public health.

Purpose of the Study:

  • To investigate the association between serum UA levels and pure tone hearing thresholds.
  • To evaluate this relationship in a large, representative sample of the U.S. general population.

Main Methods:

  • Utilized data from 44,084 participants (aged 20-69) from the National Health and Nutrition Examination Survey (1999-2004).
  • Assessed hearing thresholds at low (0.5-2 kHz) and high (3-8 kHz) frequencies.
  • Employed multivariate linear regression and tertile-based analysis with covariate adjustment.

Main Results:

  • A statistically significant inverse association was observed between higher serum UA levels and lower hearing thresholds (better hearing).
  • The association remained significant after adjusting for multiple covariates.
  • Negative trends between serum UA and hearing thresholds were significant (P for trends <0.05).

Conclusions:

  • Elevated serum UA levels are independently and inversely associated with pure tone hearing thresholds.
  • This finding suggests a protective role of higher UA levels against hearing impairment in U.S. adults.
  • Further research is needed to elucidate the underlying mechanisms.