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Updated: Mar 15, 2026
Functional Magnetic Resonance Spectroscopy at 7 T in the Rat Barrel Cortex During Whisker Activation
Published on: February 8, 2019
Detection of glucose in the human brain with 1 H MRS at 7 Tesla
Lana G Kaiser1, Kawaguchi Hirokazu1, Masaki Fukunaga2
1Siemens Healthcare KK, Tokyo, Japan.
Purpose:
A new method is proposed for noninvasive detection of glucose in vivo using proton MR spectroscopy at 7 Tesla.
Theory And Methods:
The proposed method utilizes J-difference editing to uncover the resonance of beta-glucose (β-glc) at 3.23 ppm, which is strongly overlapped with choline. Calculations using the density matrix formalism are used to maximize the signal-to-noise ratio of the β-glc resonance at 3.23 ppm. The calculations are verified using phantom and in vivo data collected at 7 Tesla.
Results:
The proposed method allows observation of the glucose signal at 3.23 ppm in the human brain spectrum. Additional co-edited resonances of N-acetylaspartylglutamatate and glutathione are also detected in the same experiment.
Conclusion:
The proposed method does not require carbon (13 C)- labeled glucose injections and 13 C hardware; as such, it has a potential to provide valuable information on intrinsic glucose concentration in the human brain in vivo. Magn Reson Med 76:1653-1660, 2016. © 2016 International Society for Magnetic Resonance in Medicine.
