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Motion-insensitive rapid configuration relaxometry.

Damien Nguyen1,2, Oliver Bieri1,2

  • 1Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland.

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Summary
This summary is machine-generated.

A new method called MIRACLE enables motion-insensitive rapid relaxometry by combining Triple Echo Steady State (TESS) with balanced SSFP scans. This technique provides accurate T1 and T2 mapping, similar to TESS but without motion sensitivity.

Keywords:
T1 mappingT2 mappingbalanced Steady State Free Precession (bSSFP)relaxometry

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Area of Science:

  • Magnetic Resonance Imaging
  • Medical Physics
  • Biomedical Engineering

Background:

  • Triple Echo Steady State (TESS) is a rapid relaxometry technique.
  • TESS utilizes unbalanced gradients, making it sensitive to motion.
  • There is a need for motion-insensitive rapid relaxometry methods.

Purpose of the Study:

  • To develop a motion-insensitive rapid relaxometry technique by merging TESS with balanced SSFP.
  • To introduce MIRACLE (Motion-Insensitive Rapid Acquisition Combination of lowest order steady state) for improved relaxometry.
  • To evaluate the performance of MIRACLE in simulations, phantoms, and in vivo imaging.

Main Methods:

  • MIRACLE retrieves lowest order steady state configurations via Fourier transformation of N frequency-shifted balanced SSFP (bSSFP) scans.
  • Relaxometry is performed on the retrieved configurations.
  • The method was validated using simulations, phantom studies, and in vivo imaging of the brain and cartilage at 3T.

Main Results:

  • Simulations and phantom studies showed no conceptual flaws in MIRACLE.
  • Artifact-free in vivo imaging was achieved.
  • Accurate relaxometry results were obtained for phantoms and cartilage; T2 mapping in the brain was in good agreement.
  • Apparent low T1 values in brain white matter were observed, attributed to bSSFP profile asymmetries.

Conclusions:

  • MIRACLE provides rapid T1 and T2 mapping with properties similar to TESS but without motion sensitivity.
  • The Fourier transformation in MIRACLE makes relaxometry sensitive to voxel frequency distribution, potentially revealing physiologic information like structural brain integrity.
  • MIRACLE represents a significant advancement for motion-insensitive quantitative MRI.