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Related Experiment Video

Updated: Mar 15, 2026

Automated 3D Optical Coherence Tomography to Elucidate Biofilm Morphogenesis Over Large Spatial Scales
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Common-path optical coherence tomography using a microelectromechanical-system-based endoscopic probe.

Donglin Wang, Can Duan, Xiaoyang Zhang

    Applied Optics
    |September 9, 2016
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a compact common-path swept-source optical coherence tomography (SSOCT) probe for endoscopic imaging. It successfully reduces artifacts and enables in vivo diagnosis within human organs.

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    Area of Science:

    • Biomedical Optics
    • Medical Imaging
    • Optical Engineering

    Background:

    • Endoscopic diagnosis requires high-resolution imaging of internal organs.
    • Traditional optical coherence tomography (OCT) systems face challenges with probe size and artifact reduction.

    Purpose of the Study:

    • To develop a miniaturized common-path swept-source OCT (CP-SSOCT) system for endoscopic applications.
    • To improve image quality by minimizing artifacts in endoscopic OCT.
    • To demonstrate the feasibility of Doppler OCT using the developed endoscopic probe.

    Main Methods:

    • Designed a novel endoscopic probe incorporating a common-path configuration.
    • Utilized the rear surface of a gradient refractive index (GRIN) lens as the internal reference reflection.
    • Optimized GRIN lens length to mitigate image artifacts.
    • Integrated a two-axis electrothermal microelectromechanical system (MEMS) mirror for image scanning.
    • Demonstrated Doppler OCT capabilities.

    Main Results:

    • Achieved successful artifact elimination in SSOCT images through GRIN lens optimization.
    • Demonstrated the capability of Doppler OCT for functional imaging.
    • Developed a compact probe with a diameter of 2.5 mm, suitable for insertion into standard endoscope biopsy channels.

    Conclusions:

    • The developed CP-SSOCT endoscopic probe offers a promising solution for minimally invasive in vivo diagnosis.
    • The system's compact design and artifact reduction capabilities enhance its clinical potential for internal organ imaging.