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Ethanol and water sorption into stratum corneum and model systems
B Berner1, R H Juang, G C Mazzenga
1CIBA-GEIGY Corporation, Ardsley, N.Y. 10502.
Journal of Pharmaceutical Sciences
|June 1, 1989
Summary
Ethanol enhances skin permeation by dehydrating skin proteins (keratins). Its solubility in lipid models like triolein increases linearly, aiding in predicting ethanol
Area of Science:
- Biophysics
- Dermatology
- Physical Chemistry
Background:
- The stratum corneum is the primary barrier to skin permeation.
- Ethanol is known to enhance the percutaneous absorption of various substances.
- Understanding the mechanisms of ethanol-water sorption is crucial for drug delivery.
Purpose of the Study:
- To investigate the sorption of ethanol and water into the stratum corneum.
- To elucidate the role of model lipids in ethanol sorption.
- To develop a predictive model for ethanol-enhanced skin permeation.
Main Methods:
- Sorption experiments with stratum corneum, delipidized stratum corneum, and triolein.
- Analysis of ethanol and water solubility and flux.
- Development of a predictive model based on solubility and diffusion.
Main Results:
- Ethanol sorption and flux optima correlate with keratin dehydration.
- A linear cosolvency was observed between ethanol and triolein.
- The proposed model qualitatively predicts ethanol-enhanced skin permeation.
Conclusions:
- Ethanol's effect on skin permeation is linked to its interaction with skin lipids and proteins.
- Keratin dehydration plays a key role in ethanol sorption and flux.
- The developed model provides a framework for understanding ethanol-enhanced transdermal delivery.