Related Experiment Video
Updated: Mar 15, 2026
Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
Published on: October 27, 2023
[Diagnostic and therapeutic approach of intraabdominal candidiasis]
Abstract:
Invasive fungal disease is associated to a high mortality rate on critical ill patients. In the last decades an important epidemiological shift has been described. Early diagnosis and treatment are related with a better prognosis. The key factors lie in a set of predictive scores that allow to identify patients that will benefit of early treatment, as well as using diagnosis techniques that are culture independent. New diagnosis approximations are being developed with promising results: in situ hybridisation using PNA-FISH probes, MALDI-TOF MS and rapid nucleic acids detection assays. The use of echinocandin is recommended as antifungal therapy on critical ill patients with candida peritonitis.
Insights
Early diagnosis of invasive fungal disease in critical patients improves outcomes. Advanced techniques like PNA-FISH and MALDI-TOF MS aid in rapid, culture-independent detection, guiding timely antifungal treatment.
Area of Science:
- Critical care medicine
- Infectious diseases
- Medical diagnostics
Background:
- Invasive fungal disease (IFD) significantly increases mortality in critically ill patients.
- An epidemiological shift in IFD has been observed over recent decades.
- Timely diagnosis and treatment are crucial for improving patient prognosis.
Purpose of the Study:
- To highlight the importance of early diagnosis and treatment for invasive fungal disease in critical care.
- To review novel, culture-independent diagnostic techniques for IFD.
- To discuss current antifungal therapy recommendations for specific IFD cases.
Main Methods:
- Review of recent epidemiological data on invasive fungal disease.
- Evaluation of emerging diagnostic technologies: PNA-FISH, MALDI-TOF MS, nucleic acid assays.
- Analysis of treatment guidelines for antifungal therapy in critical care.
Main Results:
- Predictive scores can identify patients who will benefit from early IFD treatment.
- Culture-independent diagnostic methods show promising results for rapid detection.
- Echinocandins are recommended for treating Candida peritonitis in critically ill patients.
Conclusions:
- Early detection and treatment are vital for reducing mortality from invasive fungal disease.
- New diagnostic approaches offer faster and more accurate identification of fungal pathogens.
- Optimized antifungal strategies are essential for managing IFD in critical care settings.
More Related Videos
06:50A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms
Published on: September 16, 2022
03:24Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging
Published on: March 22, 2024
Related Concept Videos
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:29Chronic Pancreatitis II: Collaborative Care
Assessment:
01:29Appendicitis-II: Diagnostic Studies and Management
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...