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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Mar 15, 2026

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
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Multifunctional AIEgens for Future Theranostics.

Guangxue Feng1, Bin Liu1,2

  • 1Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117585, Singapore.

Small (Weinheim an Der Bergstrasse, Germany)
|September 9, 2016
PubMed
Summary
This summary is machine-generated.

Simple molecules called fluorogens with aggregation-induced emission (AIEgens) offer multifunctional theranostics for advanced biomedical imaging and therapy. This approach simplifies complex systems, enhancing reproducibility in life science research.

Keywords:
aggregation-induced emissionbioimagingcancer therapymultifunctional materialstheranostics

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Molecular Imaging

Background:

  • Theranostics, combining diagnosis and therapy, is crucial in life sciences.
  • Current theranostic platforms often involve complex, multi-material integration.
  • This complexity can lead to reduced reproducibility and increased challenges.

Purpose of the Study:

  • To present frontier developments in simple, multifunctional fluorogens with aggregation-induced emission (AIEgens).
  • To highlight AIEgens as a smart molecular design for simplified theranostic systems.
  • To explore AIEgens for simultaneous imaging and therapeutic applications.

Main Methods:

  • Design of simple molecules (AIEgens) with inherent multifunctionality.
  • Integration of AIEgens into various theranostic modalities.
  • Evaluation of AIEgens for combined diagnostic and therapeutic functions.

Main Results:

  • Demonstrated AIEgens for fluorescence-photoacoustic imaging and fluorescence-magnetic resonance imaging.
  • Showcased AIEgens in fluorescence image-guided photodynamic therapy and chemotherapy.
  • Presented AIEgens for photoacoustic image-guided photothermal therapy.

Conclusions:

  • Smart molecular design of multifunctional AIEgens offers a simplified approach to theranostics.
  • AIEgens enable simultaneous imaging and therapeutic functions, addressing current platform limitations.
  • This direction promises enhanced reproducibility and innovation in biomedical research.