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Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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Related Experiment Video

Updated: Mar 15, 2026

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
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Ondansetron for pediatric concussion; a pilot study for a randomized controlled trial.

Jocelyn Gravel1, Benoit Carrière1, Antonio D'Angelo1

  • 1*Département de Pédiatrie,CHU Sainte-Justine,Université de Montréal,Montréal,QC.

CJEM
|September 10, 2016
PubMed
Summary

This pilot study assessed ondansetron for pediatric concussion symptoms. While feasibility was limited by recruitment, enrolled children completed follow-up, suggesting potential for future trials.

Keywords:
childrenconcussionmTBIondansetron

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Area of Science:

  • Pediatric emergency medicine
  • Neurology
  • Clinical trial methodology

Background:

  • Concussion is a common pediatric injury with persistent symptoms.
  • Effective treatments for post-concussion symptoms in children are needed.
  • Ondansetron is an antiemetic with potential anti-inflammatory effects.

Purpose of the Study:

  • To assess the feasibility of a randomized controlled trial evaluating oral ondansetron for reducing post-concussion symptoms in children.
  • To determine the eligibility and recruitment rates for a pediatric concussion study.
  • To evaluate patient compliance with study interventions and follow-up procedures.

Main Methods:

  • Pilot randomized, triple-blind, placebo-controlled trial.
  • Participants: Children aged 8-17 with concussion within 24 hours.
  • Intervention: Single dose of oral ondansetron or placebo.
  • Outcomes: Post-concussion symptoms at 1 week and 1 month; feasibility of follow-up assessments.

Main Results:

  • 33% of screened children were eligible (36/108).
  • 14.8% of screened children agreed to participate (16/108).
  • All enrolled patients completed the intervention and follow-up assessments.

Conclusions:

  • Recruitment feasibility was limited, with approximately one-third of eligible patients agreeing to participate.
  • Minimal noncompliance was observed, and most patients preferred electronic follow-up.
  • The study supports the feasibility of conducting a larger trial with potential recruitment strategies.