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Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
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Related Experiment Video

Updated: Mar 15, 2026

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing
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Draft genome sequence of Enterococcus faecium strain LMG 8148.

Joran E Michiels1, Bram Van den Bergh1, Maarten Fauvart2

  • 1Centre of Microbial and Plant Genetics, KU Leuven, B-3001 Leuven, Belgium.

Standards in Genomic Sciences
|September 10, 2016
PubMed
Summary

We sequenced the genome of Enterococcus faecium strain LMG 8148, isolated in 1968. This early strain provides a valuable baseline for studying the evolution of this opportunistic pathogen.

Keywords:
Draft genomeEnterococcus faeciumGut commensalHuman isolateNosocomial pathogen

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Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Enterococcus faecium is a bacterium commonly found in the gut.
  • It is increasingly recognized as a significant cause of hospital-acquired infections.
  • Multidrug resistance is a growing concern in Enterococcus faecium infections.

Observation:

  • We present the draft genome sequence of E. faecium strain LMG 8148.
  • This strain was isolated from a human in Sweden in 1968.
  • The genome is 2,697,490 bp with 2,402 predicted protein-coding sequences.

Findings:

  • The genome sequence of E. faecium LMG 8148 is now available.
  • This strain was isolated before E. faecium became a major nosocomial pathogen.
  • The genome data includes length, GC-content, and predicted genes.

Implications:

  • This genome sequence is valuable for comparative genomics.
  • It can help researchers understand how E. faecium evolved into a pathogen.
  • Understanding this evolution is key to combating antibiotic resistance.