Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Reproductive Cloning01:27

Reproductive Cloning

32.5K
Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
32.5K
Cloning of Dolly the Sheep01:08

Cloning of Dolly the Sheep

7.0K
The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual,  the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter...
7.0K
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

2.2K
Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing.

Immunity·2026
Same author

A distinct E dimer epitope underlies selective recognition by a protective human West Nile virus antibody.

EMBO reports·2026
Same author

Asymmetric structural transitions in the icosahedral organization of Eastern equine encephalitis virus.

Nature communications·2026
Same author

Human antibody targeting Crimean-Congo hemorrhagic fever virus glycoprotein 38 protects mice against heterologous virus challenge.

The Journal of clinical investigation·2026
Same author

Epitope-focused discovery of SARS-CoV-2 antibodies that potently neutralize Omicron variants.

Nature microbiology·2026
Same author

Structural basis for recognition of Rift Valley fever virus Gn protein by a human neutralizing monoclonal antibody with a kappa light chain.

PLoS pathogens·2026

Related Experiment Video

Updated: Jan 9, 2026

Manufacturing, Control, and Performance Evaluation of a Gecko-Inspired Soft Robot
07:40

Manufacturing, Control, and Performance Evaluation of a Gecko-Inspired Soft Robot

Published on: June 10, 2020

15.2K

Teaching a Clone to Walk, One Step at a Time.

James E Crowe1

  • 1Departments of Pediatrics, Pathology, Microbiology, and Immunology and Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Cell
|September 10, 2016
PubMed
Summary

Developing effective HIV vaccines requires overcoming challenges in antibody generation. New structure-based designs for sequential boosting regimens show promise for an HIV vaccine strategy.

Area of Science:

  • Immunology
  • Virology
  • Vaccine Development

Background:

  • Broadly neutralizing antibodies (bNAbs) are crucial for controlling HIV infection.
  • Natural HIV infection typically requires prolonged exposure to diverse viral variants for bNAb development.

Purpose of the Study:

  • To explore structure-based antigen design for eliciting potent HIV broadly neutralizing antibodies.
  • To investigate sequential boosting regimens with progressively maturing antigens as an HIV vaccine strategy.

Main Methods:

  • Structure-based computational design of HIV antigens.
  • Immunization of animal models with sequential antigen boosts.
  • Analysis of antibody responses, including neutralization breadth and potency.

More Related Videos

Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion
08:19

Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion

Published on: January 15, 2016

9.2K
SSVEP-based Experimental Procedure for Brain-Robot Interaction with Humanoid Robots
11:01

SSVEP-based Experimental Procedure for Brain-Robot Interaction with Humanoid Robots

Published on: November 24, 2015

13.7K

Related Experiment Videos

Last Updated: Jan 9, 2026

Manufacturing, Control, and Performance Evaluation of a Gecko-Inspired Soft Robot
07:40

Manufacturing, Control, and Performance Evaluation of a Gecko-Inspired Soft Robot

Published on: June 10, 2020

15.2K
Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion
08:19

Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion

Published on: January 15, 2016

9.2K
SSVEP-based Experimental Procedure for Brain-Robot Interaction with Humanoid Robots
11:01

SSVEP-based Experimental Procedure for Brain-Robot Interaction with Humanoid Robots

Published on: November 24, 2015

13.7K

Main Results:

  • Successfully designed novel HIV antigens that elicit specific antibody lineages.
  • Demonstrated that sequential boosting with maturing antigens can guide antibody development towards bNAbs.
  • Achieved enhanced neutralization of diverse HIV strains compared to non-sequential regimens.

Conclusions:

  • Structure-based antigen design is a viable approach for developing effective HIV vaccines.
  • Sequential boosting strategies with optimized antigens represent a promising path forward for HIV vaccine development.